Table 1.
Lupus nephritis: baseline patient demographics [N = 89]
| Variable | n (% of 89) | Mean ± SD† | |
|---|---|---|---|
| Demographics | |||
| Age in years | 15.6±3.2 | ||
| Gender | Female: male | 71: 18 (81%: 19%) | |
| Race | African American | 37 (42%) | |
| Caucasian | 39 (43%) | ||
| Asian | 7 (8%) | ||
| Others | 6 (7%) | ||
| Ethnicity | Hispanic/Non-Hispanic | 10: 79 (11%: 89%) | |
| Blood pressure | Systolic (mmHg) | 124.4 ± 15.2 | |
| Diastolic (mmHg) | 73.0±11.2 | ||
| Clinical and laboratory descriptors | |||
| Disease activity | Renal SLEDAIΔ | 7.8 ±5.2 | |
| Extra-renal SLEDAI | 6.6 ±6.4 | ||
| Renal damage | Renal SDI* | 0.04 (0.19) | |
| Standard laboratory tests | Protein: creatinine ratio | 2.9±3.3 | |
| Serum creatinine (mg/dL) | 0.85 ±0.6 | ||
| GFR (mL/min/1.73m2) ‡ | 133.7 ±58.9 | ||
| Active urinary sediment | 58 (65%) | ||
| Angiotensin-blocking drugs | 32 (36%) | ||
| Kidney biopsy interpretation | |||
| ISN/RPS class** | Class II | 8 (9%) | |
| Class III | 16(18%) | ||
| Class IV | 35 (40%) | ||
| Class V | 29 (33%) | ||
| NIH-AI score& | 8.0±6.6 | ||
| NIH-CI score$ | 1.7±1.3 |
Standard deviation
SLE disease activity index
Systemic Lupus Collaborating Clinics/American College of Rheumatology Damage Index
Glomerular filtration rate as per the modified Schwartz formula (Schwartz GJ et al.; J Am Soc Nephrol. 2009; 629-637)
Active urinary sediment refers to the presence of cellular casts, white cells > 5 per high power field, and/or red cells > 5 per high power field in the urine specimen
International Society of Nephrology/Renal Pathology Society. Overlap with class 5 is summarized under class 3 and 4 as appropriate
National Institutes of Health Activity Index score; range, 0-24; 0 = inactive lupus nephritis
National Institutes of Health Chronicity Index score; range, 0-12; 0 =no lupus nephritis damage