Table 4.
Prediction of LN damage status considering urine biomarkers and traditional measures of renal function
| Adiponectin and osteopontin (unadjusted) |
Adiponectin and osteopontin standardized by proteinuria Correction for LN activity |
Adiponectin and osteopontin standardized by urine creatinine |
|||
|---|---|---|---|---|---|
| No consideration of LN activity |
Correction for LN activity |
Correction for LN activity |
Correction for GFR and LN activity |
||
| AUC ±95% confidence | 0.75± 0.13 | 0.74 ±0.13 | 0.77 ±0.12 | 0.76±0.12 | 0.79 ±0.12 |
| interval | |||||
| Adjusted R2 | 0.23 | 0.24 | 0.27 | 0.24 | 0.34 |
| Threshold score | −0.31 | −0.44 | −0.48 | 0.0 | 0.0 |
| LR test (p value) | 11.6 (0.003) | 12.0 (0.007) | 13.0 (0.01) | 11.6 (0.02) | 16.0 (0.007) |
| Sensitivity/specificity | 80.6%/66.7% | 80.0%/66.7% | 79.3% 62.1% | 65.5%/69.0% | 69.0%/61.5% |
| PPV/NPV | 71.4%/76.9% | 68.6%/76.0% | 67.6%/75.0% | 67.9%/66.7% | 66.7%/64.0% |
| LR+/LR- | 2.42/0.29 | 2.40/0.30 | 2.09 0.33 | 2.11/0.50 | 1.79/0.50 |
| Parameter details STB ± SD (p value) | |||||
| Intercept | 1.11 ±0.44 (0.23) | 0.64 ±1.03 (0.53) | 2.71 ±2.20 (0.22) | 2.65 ±1.98 (0.18) | 5.66 ±2.60 (0.03) |
| Osteopontin | −0.55 ±0.20 (0.006) | −0.51±0.20 (0.011) | −2.92 ±1.18 (0.014) | −1.70 ±0.91 (0.06) | −0.93 ±0.97 (0.34) |
| Adiponectin | 0.32±0.15 (0.035) | 0.32± 0.16 (0.049) | 1.95 ±1.17 (0.10) | 1.24 ±0.75 (0.10) | 1.07 ±0.75 (0.15) |
| LN activity (NIH-AI) | 0.03 ±0.05 (0.56) | 0.01 ±0.05 (0.80) | 0.02 ±0.05 (0.63) | −0.05 ±0.06 (0.42) | |
| Standardization for proteinuria | −0.33 ±0.26 (0.20) | ||||
| Standardization for creatinine | −0.52±0.33 (0.11) | −0.60 ±0.35 (0.09) | |||
| Glomerular filtration rate | −0.02 ±0.01 (0.03) | ||||
LN lupus nephritis, NIH-A1N1H activity index, GFR glomerular filtration rate, PPV positive predictive values, NPV negative predictive value, LR+ likelihood ratio for a positive test, LR- likelihood ratio of a negative test, STB standardized beta coefficient, SD standard deviations