Table 1. Comparisons of baseline characteristics among UA groups according to the mean serum UA level within the first year after transplantation in the 1-YR analysis.
| UA groups for 1-YR analysis | ||||
|---|---|---|---|---|
| Variables | Low (n = 252) |
Normal (n = 1566) |
High (n = 676) |
P value |
| Transplant era | <0.001 | |||
| 1992–2003 | 94 (37.3%)†‡ | 751 (47.8%)*‡ | 426 (62.6%)*† | |
| 2004–2014 | 158 (62.7%) | 819 (52.2%) | 254 (37.4%) | |
| Age (years) | 43.5 ± 11.3†‡ | 41.3 ± 11.1*‡ | 39.5 ± 10.9*† | <0.001 |
| Sex, male | 158 (62.7%) | 999 (63.6%) | 430 (63.2%) | 0.95 |
| BMI (kg/m2) | 21.7 ± 2.9 | 21.8 ± 3.1 | 22.0 ± 3.2 | 0.12 |
| Donor type, deceased | 15 (6.0%)†‡ | 211 (13.4%)*‡ | 146 (21.5%)*† | <0.001 |
| Donor age (years) | 38.0 ± 10.2‡ | 39.0 ± 11.9 | 40.1 ± 12.5* | 0.02 |
| Donor sex, male | 108(42.9%)†‡ | 870 (55.4%)* | 400 (58.8%)* | <0.001 |
| Pretransplant DM | 47 (18.7%)†‡ | 169 (10.8%)*‡ | 23 (3.4%)*† | <0.001 |
| Duration of pretransplant dialysis (months) |
15.4 ± 29.4†‡ | 26.4 ± 40.2*‡ | 36.3 ± 46.2*† | <0.001 |
| Retransplantation | 14 (5.6%) | 143 (9.1%) | 64 (9.4%) | 0.15 |
| Number of HLA mismatches | 2.5 ± 1.3 | 2.5 ± 1.2 | 2.4 ± 1.2 | 0.60 |
| Tacrolimus use | 101 (40.1%)† | 624 (39.7%)* | 236 (34.7%) | 0.07 |
| Delayed graft function | 1 (0.4%)†‡ | 49 (3.1%)*‡ | 53 (7.8%)*† | <0.001 |
| BPAR within 1 year | 17 (6.7%)†‡ | 295 (18.8%)*‡ | 225 (33.1%)*† | <0.001 |
| SBP at 1 month (mmHg) | 129.3 ± 13.7‡ | 129.9 ± 14.4‡ | 132.8 ±14.6*† | <0.001 |
| DBP at 1 month (mmHg) | 83.0 ± 10.2‡ | 83.2 ± 10.3‡ | 85.0 ± 10.9*† | 0.001 |
| eGFR at 1 month (mL/min) | 72.9 ± 17.9†‡ | 65.6 ± 19.7*‡ | 56.2 ± 20.9*† | <0.001 |
| eGFR at 1 year (mL/min) | 73.7 ± 16.0†‡ | 67.8 ± 16.9*‡ | 58.6 ± 17.4*† | <0.001 |
| Mean serum UA within 1st year (mg/dL) | 3.69 ± 0.52†‡ | 5.47 ± 0.78*‡ | 7.68 ± 1.15*† | <0.001 |
*P<0.05 versus the low-UA group
†P<0.05 versus the normal-UA group
‡P<0.05 versus the high-UA group in the post-hoc analysis
UA, uric acid; BMI, body mass index; DM, diabetes mellitus; HLA, human leukocyte antigen; BPAR, biopsy-proven acute rejection; SBP, systolic blood pressure; DBP, diastolic blood pressure; eGFR, estimated glomerular filtration rate