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. 2018 Dec 14;13(12):e0209295. doi: 10.1371/journal.pone.0209295

Table 2. Results of PDX assays of CD25-positive AML.

		Primary transplantation						Secondary transplantation
Patient	Sample type	Transplanted cells	No. of transplanted cells (× 10³)	No. of mice transplanted	No. of mice analyzed^*	No. of mice engrafted	Type of engraftment	Transplanted cells	No. of transplanted cells (× 10³)	No. of mice transplanted	No. of mice analyzed^*	No. of mice engrafted	Type of engraftment
AML01	PB	CD34⁺CD38^–CD25⁺	90	2	2	2	Leukemic	CD34⁺CD25⁺	100	2	1	1	Leukemic
								CD34⁺CD25^–	100	4	3	2	Leukemic
		CD34⁺CD38^–CD25^–	100	2	2	2	Leukemic	CD34⁺CD25⁺	20	2	2	2	Leukemic
								CD34⁺CD25^–	20	4	3	2	Leukemic
AML02	PB	CD34⁺CD38^–CD25⁺	100	3	2	2	Leukemic	CD34⁺CD25⁺	100	4	2	1	Leukemic
								CD34⁺CD25^–	30	2	1	1	Leukemic
		CD34⁺CD38^–CD25^–	100	2	2	2	Leukemic	CD34⁺CD25⁺	100	3	2	1	Leukemic
								CD34⁺CD25^–	60	2	1	1	Leukemic
AML03	BM	CD34⁺CD25⁺	100	4	3	3	Leukemic	–	–	–	–	–	–
		CD34⁺CD25^–	100	4	2	2	Leukemic	–	–	–	–	–	–
AML04	BM	CD34⁺CD25⁺	33	7	1	1	Leukemic	hCD45⁺	100	4	3	0	–
		CD34⁺CD25^–	33	2	1	1	Multi-lineage	–	–	–	–	–	–
AML05	PB	CD34⁺CD25⁺	100	4	2	0	No engraftment	–	–	–	–	–	–
		CD34⁺CD25^–	100	4	2	2	Leukemic	hCD45⁺	10	3	3	0	–
AML06	PB	CD34⁺CD38^–CD25⁺	50	4	3	1	Leukemic	hCD45⁺	30	3	3	0	–
AML07	BM	CD34⁺CD25⁺	10	2	1	0	No engraftment	–	–	–	–	–	–
		CD34⁺CD25^–	10	4	1	0	No engraftment	–	–	–	–	–	–
AML08	BM	CD34⁺CD25⁺	100	3	3	0	No engraftment	–	–	–	–	–	–
		CD34⁺CD25^–	100	3	3	0	No engraftment	–	–	–	–	–	–
AML09	BM	CD34⁺CD25⁺	15	3	2	0	No engraftment	–	–	–	–	–	–
		CD34⁺CD25^–	15	2	2	0	No engraftment	–	–	–	–	–	–

–, data not available; AML, acute myeloid leukemia; BM, bone marrow; hCD45, human CD45; PB, peripheral blood.

* A number of mice transplanted with cells from AML03, 04, 05, 06, 07, or 09 died before the analysis.