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. 2018 Dec 14;13(12):e0208608. doi: 10.1371/journal.pone.0208608

Table 9. Correlation between treatment period and safety and efficacy (Pearson Chi-Square).

Safety Efficacy
Below cut-off (< = 0.85) Above cut-off (>0.85) Sig. (2-sided) Below cut-off (< = 0.8) Above cut-off (>0.8) Sig. (2-sided)
Treatment period 2002–2006 Percentage 551 3725 p<0.001 491 3785 p<0.001
Count 12.9% 87.1% 11.5% 88.5%
2007–2010 Percentage 127 2756 472 2411
Count 4.4% 95.6% 16.4% 83.6%
2011–2015 Percentage 37 1577 264 1350
Count 2.3% 97.7% 16.4% 83.6%

P-value indicates association between treatment period and outcome above/below cut-off.