Table 10. Logistic regression model–safety.

Variable		Sig.		Adjusted OR		95% C.I. for OR
						Lower	Upper
Age			p<0.001		0.969	0.961	0.977
SEQ before Treatment	0 to (-3) D		p<0.001		3.293	2.367	4.581
	(-3.01) to (-6) D		p<0.001		3.634	2.651	4.981
	(-6.01) to (-9) D		p<0.001		2.138	1.533	2.982
	SEQ> -9 D		p<0.001		1.0	* reference category
Treatment period	2002–2006		p<0.001		1.0	* reference category
	2007–2010		p<0.001		3.577	2.889	4.429
	2011–2015		p<0.001		7.598	5.353	10.785

SEQ = spherical equivalent; OR = odds ratio; C.I = confidence interval

SEQ before treatment and treatment period—OR value is regarding the reference category. Age—OR value is relative to an increase of one year