Figure 1.

Progression of parkinsonism and Tyrosine hydroxydase (TH) immunolabeling in the basal ganglia. Plots A, B, and C show parkinsonism rating scores from monkeys A, B, and C, respectively, throughout the development of parkinsonism. The number of behavioral observations across is indicated below each column. Note that we only had baseline and stage 3 scores available for monkey C. The summary scores shown here are averages of groupings of the individual parkinsonism rating scores in each of the severity states. The akinesia summary score (white) includes subscores for freezing and akinesia of the right leg and arm. The posture score (light grey) includes subscores for balance, trunk and extremity postures. The bradykinesia summary score (dark grey) is the sum of the subscores for home cage behavior and bradykinesia. The dexterity score (black) includes the subscores for (kinetic) tremor and finger dexterity. D Data shows TH staining in a normal monkey and in monkey C treated with MPTP, demonstrating the substantial reduction of TH staining in the treated animal. TH labeling results from monkeys A and B were similar, and shown in a previous publication (Devergnas et al. 2014). CN, caudate nucleus; Put, putamen; SN, substantia nigra. Scale bar (1 mm) in the left image applies to both images.