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. 2018 Oct 24;29(1):397–409. doi: 10.1093/cercor/bhy264

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© The Author(s) 2018. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 4. — Relating signal variability and functional connectivity | (a) Mean changes in functional connectivity following dopamine depletion were estimated across all nodes and correlated with changes in within-region signal variability. Changes in functional connectivity are related to changes in signal variability, such that the larger the increase in signal variability, the larger the decrease in functional connectivity. (b) Mean changes in functional connectivity for intrinsic networks are correlated with mean changes in local signal variability in those networks. There is a clear anti-correlation between the two, consistent with the result in part (a). (c) The mean changes in functional connectivity was calculated for each network and assessed by permutation tests (10 000 repetitions). Mean connectivity significantly decreases in temporal, salience and somatomotor networks. Somatomotor and salience networks also experience significant increase in local variability (Fig. 3). (d) Mean functional connectivity in depletion (APTD) versus non-depletion (BAL) conditions, shown for nodes belonging to the temporal (TEM), somatomotor (SM) and salience (SAL) networks. Functional connectivity decreases in all instances (permutation test; FDR corrected).