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. Author manuscript; available in PMC: 2019 Oct 1.
Published in final edited form as: Curr Pharmacol Rep. 2018 Jun 30;4(5):346–357. doi: 10.1007/s40495-018-0147-0

Table 1.

A brief list of idiosyncratic DILI-inducing drugs, their indication and the associated immune response.

Representative IDILI- Inducing Drugs
Drug Indication: Immune Response: DILI Reference
Halothane volatile anesthetic eosinophils, NKT cells [92]
Diclofenac NSAID TH17 response including neutrophils and T cells [101]
Tienilic Acid loop diuretic cellular necrosis and surrounding inflammation [102]
Dihydralazine anti-hypertensive acute hepatitis [103]
Isoniazid antibiotic CYP2E1 Autoantibodies [104]
Amodiaquine antiparasitic T-Cell mediated, may involve PD-1 [93]
Flucloxacillin antibiotic T-Cell mediated, especially CD8+ [105]