Table 1.
Representative IDILI- Inducing Drugs | |||
---|---|---|---|
Drug | Indication: | Immune Response: | DILI Reference |
Halothane | volatile anesthetic | eosinophils, NKT cells | [92] |
Diclofenac | NSAID | TH17 response including neutrophils and T cells | [101] |
Tienilic Acid | loop diuretic | cellular necrosis and surrounding inflammation | [102] |
Dihydralazine | anti-hypertensive | acute hepatitis | [103] |
Isoniazid | antibiotic | CYP2E1 Autoantibodies | [104] |
Amodiaquine | antiparasitic | T-Cell mediated, may involve PD-1 | [93] |
Flucloxacillin | antibiotic | T-Cell mediated, especially CD8+ | [105] |