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. 2018 Nov 5;46(22):11847–11857. doi: 10.1093/nar/gky1065

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© The Author(s) 2018. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 6. — (A) Pif1–PCNA interaction is important for replication through G4 structures. Replication time of 30 Kb through G4_(A+B) located on the lagging strand in strains with pif1-R3Emut (n = 26)(18), pif1-PIPmut (n = 25) shown in blue and pif1-m2 (n = 26) in comparison to WT, pif1Δ (Figure 2C). Significance was determined by Monte Carlo resampling *P< 0.05, **P< 0.005. Error bars are ± SEM. (B) DNA primer extension activity of Pol δ past G4_(B) in the presence of the ^Δ237Pif1 wild-type or its Pif1-PIPmut variant containing the F760A Y761A mutations. Standard deviations are from five independent experiments.