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. 2018 Oct 10;46(22):11789–11805. doi: 10.1093/nar/gky928

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© The Author(s) 2018. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 5. — R-loop accumulation in RNA Pol II transcription units is strongly associated with polyadenylation sites. (A) Metaplots and heatmaps of WT and Tbrh1–/– DRIP signal over the CDS ±1 kb of each Pol II transcribed gene. (B) Metaplots of the number of UTR- or intergenic-associated DRIP enriched regions (red) and PAS (blue) regions per bp for each Pol II CDS ±5 kb for WT (upper) and Tbrh1–/– (lower) DRIP-seq data. (C) Prepresentative screenshot of WT DRIP signal (pink) relative to mapped PAS (blue; predominantly used PAS in dark blue) and SAS (orange) locations in a region of chromosome 5; CDS and DRIP-seq enrichment annotations are as shown as in Figure 1.