Figure 3.

Ey binding at promoters is associated with active transcription of genes at the isoform level. (A) Ey can selectively bind the promoters of specific isoforms of a gene. The left pie chart shows the fraction of genes with multiple isoforms that are bound by Ey at the promoters. The right chart shows the fraction of genes with Ey binding to the promoters of multiple isoforms versus only a single isoform. (B) Pie chart showing percentage of isoform specific Ey peaks that coincide with PolII peaks. (C–E) Examples showing the isoforms bound by Ey are transcribed in third larval instar eye discs and corresponding ChIP-Seq profiles of Ey and PolII at the promoters.