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. 2018 Oct 18;46(22):11759–11775. doi: 10.1093/nar/gky923

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© The Author(s) 2018. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 6. — Satellite repeat RNAs are involved in chromocenter reorganization during muscle differentiation. (A) Schematic of the structure of the peri/centromeric region that consists of MajS and MinS repeats. The location of antisense oligonucleotides (ASOs) for targeting satellite RNAs is demonstrated. (B) RT-qPCR for MajS, MinS and ChRO1 RNAs in ASO-treated MTs (Day 3). n.s.: not significant. (C) DAPI-staining of nuclei from MTs treated with MajS- or MinS-specific ASOs (left). The number of chromocenters is shown at right. (D) RT-qPCR for MyHC and MCK in MajS- or MinS-depleted MTs (Day 3). (E) RNA-FISH for ChRO1 in MajS- or MinS-ASO treated MTs (Day 3). (F) Schematic of ChRO1-mediated large-scale reorganization of constitutive heterochromatin during myogenesis.