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. 2018 Oct 24;46(22):12166–12176. doi: 10.1093/nar/gky970

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© The Author(s) 2018. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — Structure and structural comparison of mTREX2–duplex DNA complex. (A) DNA structural comparison of mTREX2–duplex DNA complex and mTREX2-Y-shaped DNA complex. The scissile strand and non-scissile strand of duplex DNA in mTREX2–duplex DNA complex are colored red and pink, respectively. The bottom panel shows the DNA sequence of duplex DNA. The Y-shaped DNA in mTREX2-Y-shaped DNA complex is displayed in transparent mode and colored blue and green. (B) Close view of the DNA terminal binding region of mTREX2. The DNA termini stacking cluster are colored red and displayed by stick and surface modes. The DNA from other asymmetric unit is colored gray or black. (C) Schematic comparison of the DNA terminal of mTREX2–duplex DNA complex and mTREX2-Y-shaped DNA complex structures. The active sites are displayed as pink balls.