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. 2018 Oct 26;46(22):12008–12021. doi: 10.1093/nar/gky1011

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© The Author(s) 2018. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 7. — Model of MARF1-mediated mRNA decay. MARF1 binds to a target mRNA via its RRMs. The MARF1 NYN endonuclease cleaves the target mRNA, which is subsequently decapped by the DCP1:DCP2 complex and degraded by XRN1 (not shown). Of note, MARF1-binding sites on targeted mRNAs have yet to be experimentally validated.