Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Evolutionary pathways for generalist or specialist enzymes. Potential evolutionary pathways showing how I-LtrI can transition from generalist to specialist cleavage preference on the cognate ATAC substrate to the ATCC or TTTC substrates. Plots are of I-LtrI variants with fitness values >6 for the indicated substrates, colored by number of amino acid substitutions in the co-evolving network relative to the wild-type AEGE network. Lines connect one evolutionary pathway.
