Figure 2. White matter tracts significantly correlated with fatigue in patients with multiple sclerosis.

Significant regions correlated with Modified Fatigue Impact Scale (MFIS) total (A), physical (B), and cognitive (C), treating age as a covariate of no interest, are displayed in red/yellow (gradient of significance level red < yellow). Results are shown overlaid on the mean diffusivity skeleton, both displayed in green (nonsignificant regions). White matter voxels with lesions were excluded and therefore only the normal-appearing white matter was considered for the analysis. Cluster-based thresholding corrected for multiple comparisons controlling for family-wise error rates, with p values < 0.05 considered statistically significant.