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. 2018 Nov 6;46(22):11939–11951. doi: 10.1093/nar/gky1093

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© The Author(s) 2018. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — Top hit proteins dissociated from the RNAP II/U1 snRNP machinery in ALS protein KOs. The top ranked (by fold change) proteins that dissociated from the RNAP II/U1 snRNP machinery in each KO line are shown. The rank, HGNC official symbol, calculated molecular weight (kD), best-known function, and fold change relative to wild type are shown. Functions in splicing (pink), transcription (txn, orange), DNA damage response (green), tRNA splicing ligase complex (purple) and other (black) are indicated.