Table 1.

Interface area between protein and aptamer in thrombin–TBA–K (PDB code: 4DII) and thrombin–NU172–K complexes.

	TBA	NU172
Whole interface	543 Å2	590 Å2
Thrombin A-region	282 Å2 (Thy3–Thy4)a	324 Å2 (Gua13–Gua18–Thy19)a
Thrombin B-region	183 Å2 (Thy12–Thy13)a	215 Å2 (Thy9–Thy10)a

^aIn parentheses the aptamer nucleobases that make interactions with thrombin exosite I in A- and B-region.