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(A) Shikonin increased the expression of cleaved caspase-3 and Bax, while decreased Bcl-2 expression of H1650/R and H1975/R cells compared with control group. (B) Shikonin down-regulated the expressions of p-PI3K, p-Akt of H1650/R and H1975/R cells compared with control group. *Statistically significant difference compared with control group (P<0.05).
