Table 1:
Correlation between Nuclear PRMT5 expression and the clinico-pathologic factors of breast cancer
| Variable | Nucl PRMT5 low | Nucl PRMT5 high | P* | |
|---|---|---|---|---|
| No. (%) | No. (%) | |||
| 141 (36.2) | 249 (63.8) | |||
| Age (Yr) | -Mean (± SD) | 57.1 (±3.6) | 59.7 (±11.8) | 0.05† |
| Age groups | - ≤50y | 45 (31.9) | 57 (22.9) | 0.05 |
| - >50y | 96 (68.1) | 192 (77.1) | ||
| BMI | - ≤25 | 81 (58.7) | 153 (64.3) | 0.281 |
| - >25 | 57 (41.3) | 85 (35.7) | ||
| T. size | - ≤2cm | 65 (46.1) | 155 (62.2) | 0.002 |
| - >2cm | 76 (53.9) | 94 (37.8) | ||
| LN invasion | -No | 64 (45.4) | 99 (39.8) | 0.28 |
| -Yes | 77 (54.6) | 150 (60.2) | ||
| SBR grade | -Gr 1 | 19 (13.5) | 53 (21.3) | <0.001 |
| -Gr 2 | 46 (35.6) | 136 (54.6) | ||
| -Gr 3 | 76 (53.9) | 60 (24.1) | ||
| ERα status | -Negative | 40 (28.4) | 10 (4.0) | <0.001 |
| -Positive | 101 (71.6) | 239 (96.0) | ||
| PR status | -Negative | 53 (37.6) | 46 (18.5) | <0.001 |
| -Positive | 88 (62.4) | 203 (81.5) | ||
| Her 2 status | -Negative | 71 (89.9) | 132 (93.0) | 0.42 |
| -Over-expressed | 8 (10.1) | 10 (7.0) | ||
*
Correlation by Pearson’s Chi square test unless otherwise specified
†
Difference between means by Student’s T test