Table 2:
Correlation between Nuclear PRMT5 expression and the different biomarkers studied by IHC
| Variable | Nucl PRMT5 low |
Nucl PRMT5 high |
P* | |
|---|---|---|---|---|
| No. (%) | No. (%) | |||
| 141 (36.2) | 249 (63.8) | |||
| Nucl. pAKT | -Low (≤50) | 87 (64.9) | 95 (39.7) | <0.001 |
| -High (>50) | 47 (35.1) | 144 (60.3) | ||
| Cytopl. pAKT | --Low (≤100) | 120 (88.9) | 189 (78.8) | 0.013 |
| -High (>100) | 15 (11.1) | 51 (21.2) | ||
| Nucl. LKB1 | -Low (=0) | 77 (57.0) | 110 (46.2) | 0.045 |
| -High (>0) | 58 (43.0) | 128 (53.8) | ||
| Cytopl. LKB1 | -Low (≤140) | 79 (58.5) | 150 (62.5) | 0.448 |
| -High (>140) | 56 (41.5) | 90 (37.5) | ||
| P4E-BP1 | -Low (≤50) | 66 (48.9) | 130 (53.7) | 0.368 |
| -High(>50) | 69 (51.1) | 112 (46.3) | ||
| P85-pS6K | -Low (≤90) | 94 (66.7) | 174 (71.9) | 0.281 |
| -High (>90) | 47 (33.3) | 68 (28.1) | ||
| PS6-RP | -Low (≤100) | 105 (77.2) | 178 (73.6) | 0.432 |
| -High (>100) | 31 (22.8) | 64 (26.4) | ||
| Menin | -Low (≤100) | 65 (50.4) | 84 (38.0) | 0.024 |
| -High (>100) | 64 (49.6) | 137 (62.0) | ||
| Cytopl IGF1-R | -Low (≤100) | 81 (60.4) | 109 (45.0) | 0.004 |
| -High (>100) | 53 (39.6) | 133 (55.0) | ||
*
Correlation by Pearson’s Chi square test