. Author manuscript; available in PMC: 2019 Dec 1.

Published in final edited form as: Am Heart J. 2018 Oct 2;206:51–60. doi: 10.1016/j.ahj.2018.09.014

Table II.

Association between CAD severity (reference = sex-specific “no CAD”) and 5-year mortality within each sex

CAD severity	No. of patients (% within sex)	KM estimate (95% CI) for mortality at 5 y	Unadjusted model		Adjusted model^*
CAD severity	No. of patients (% within sex)	KM estimate (95% CI) for mortality at 5 y	HR (95% CI)	P value	HR (95% CI)	P value
Women
No CAD	3699 (42.2)	8.6 (7.7–9.6)	Ref		Ref
Nonobstructive	2209 (25.2)	16.1 (14.6–17.8)	1.93 (1.65–2.25)	<.0001	1.36 (1.16–1.60)	.0002
Obstructive	2858 (32.6)	24.2 (22.7–25.9)	3.08 (2.69–3.53)	<.0001	1.86 (1.61–2.16)	<.0001
Men
No CAD	2661 (22.9)	11.5 (10.3–12.8)	Ref		Ref
Nonobstructive	2446 (21.0)	19.0 (17.4–20.6)	1.71 (1.48–1.98)	<.0001	1.24 (1.06–1.45)	.0067
Obstructive	6531 (56.1)	21.5 (20.5–22.5)	1.98 (1.74–2.24)	<.0001	1.38 (1.20–1.59)	<.0001

KM, Kaplan-Meier.

Adjusted model includes the following covariates: age, race, BMI, prior MI, diabetes, hypertension, hyperlipidemia, peripheral vascular disease, congestive heart failure, chronic obstructive pulmonary disease, renal disease, smoking history, noncardiac Charlson comorbidity index >1, and year of cath. Interaction between CAD severity and sex was significant in both the unadjusted and adjusted models (interaction P < .001 for both).