Table 2.

Factors Associated with Baseline LFS and 0 to 96 Week Change in LFS in Univariable and then Multivariable Linear Regression

	Baseline LFS		0 to 96 Week Change in LFS
	Univariable Modelsa	Multivariable Modelb	Univariable Modelsa	Multivariable Modelb
Group (1=statin)	-	-	0.094 (p=0.49)	0.165 (p=0.06)
Baseline Liver Fat Score c	-	-	1.426*	0.777*
Sex (1=male)	−0.088 (p=0.09)	-	-	-
BMI, per kg/mm2	0.012*	-	0.041*
Waist to hip ratio	1.496*	-	3.275*	-
Trunk fatc	0.005*	0.003*	0.001*	-
Insulin Resistance	0.042*	0.032*	0.045*	0.104*
Hemoglobin A1C, per %	0.190*	-	0.332 (p=0.03)	-
Hepatitis C co-infection		0.11 (p=0.03)	-	-
Hepatitis B co-infection	0.21 (p=0.03)	0.01 (p=0.09)	-	-
≥4 alcohol drinks per day	−0.199 (p=0.13)	-	-	-
Nadir CD4+, per 100 cells	−0.022 (p=0.13)	-	-	-
ART duration, per month	0.001*	0.001 (p=0.05)	-	-
HIV-1 RNA ≤48 copies/ml)	-	-	−0.278 (p=0.10)	−0.256 (p=0.02)
Interleukin-6c	-	-	0.181 (p=0.13)	-
C-X-C motif chemokine ligand 10c	1.636*	0.853 (p=0.02)	5.361*	2.579 (p=0.04)
TNFRSF1Ac	5.519 (p=0.07)	-	-	-
ICAM1c	0.003 (p=0.04)	-	-	-
%CD8+CD38+HLA-DR+c	-	-	0.270 (p=0.06)	-
Soluble CD14c	−0.628 (p=0.05)	−0.487*	-	-
Soluble CD163c	0.857*	0.376 (p=0.02)	1.225 (p=0.09)	-
%CD14dimCD16+c	0.043 (p=0.05)	-	0.159 (p=0.03)	-
0–96 week change LDL-C			−0.004 (p=0.12)	-
0–96 week change in HOMA-IR			0.054*	0.13*

Values shown are parameter estimate (p-value);

^*p≤0.01

^aOnly randomization group and those variables with p<0.15 are shown.

^bMultivariable models selected using backwards elimination from all variables with p<0.15 in univariable analysis.

^cBox cox transformed variable

BMI, body mass index; TNFRSF1A, TNF receptor superfamily member 1A; ICAM1, intercellular cell adhesion molecule 1.