Fig 4.

Analysis of the retinal morphology. Semithin sections reveal morphologic alterations in the retinae of mutant mice. (A, B) Retina of a wild type animal at 3 and 18 months of age. (C, D) Retina of mutant animals at 3 and 18 months of age. (E) For the quantification of photoreceptor nuclei the number of nuclei in a section of 100 µm was counted at defined distances from the optic nerve head (n = 2 animals per group). Standard deviations are shown. INL: inner nuclear layer; IS: inner segments; ONL: outer nuclear layer; OPL: outer plexiform layer; OS: outer segments; RPE: retinal pigmented epithelium.