Fig 5.

In vivo imaging of the retina using optical coherence tomography (OCT). (A) Retina of wild type and mutant animals were examined in the central or peripheral part (5 disk diameter distance) of the retina. The white brackets in the B scans indicate the outer retinal bands region. The green or black line in the fundus photographs highlights the area where the OCT scans was obtained. Scale bar: 50 µm. (B) Timeline of OCTs from the peripheral scans from wild type animals (3 and 15 months) and from mut at 3, 6, 9, 12, 15, 18, 21, and 24 months. (C) Entire retina and ONL thickness in wild type and mutant animals were quantified between 3 and 24 months of age (n = 4 animals per group). CH: choroid; ELM: external limiting membrane; GCL: ganglion cell layer; INL: inner nuclear layer; IPL: inner plexiforme layer; IS: inner segments; ISe: inner segments ellipsoid; ONL: outer nuclear layer; OPL: outer plexiforme layer; OS: outer segments; RPE: retinal pigmented epithelium; RNFL: retinal nerve fiber layer; * P < 0.05. (Color version of figure is available online.)