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. 2018 Jul 23;23(12):2324–2346. doi: 10.1038/s41380-018-0090-9

Fig. 3.

Fig. 3

Fig. 3

Fig. 3

(a-o) Antidepressants and D609 induce activation of Ulk and Beclin as well as expression of p62 in the Cornu ammonis of the hippocampus. Phosphorylation or expression of Ulk, Beclin, or p62 was determined by immunostaining paraffin sections from the hippocampus of wild-type, Asm-deficient, and Asm-transgenic mice with phosphospecific antibodies to Ulk serine 757 and phospho-Beclin or with anti-p62 antibodies, followed by staining with Cy3-labeled secondary antibodies. Mice were stressed by corticosterone or chronic unpredictable environmental stress (CUS) and treated with amitriptyline, fluoxetine, or D609. Samples were analyzed by confocal microscopy. Shown are representative results from 6 mice each. For quantification please see Supplementary Figure 6

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