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. 2018 Dec 14;8:17860. doi: 10.1038/s41598-018-36215-4

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Cygb-TG mice exhibited ameliorated inflammation after 10 weeks of TAA treatment. WT and Cygb-TG (TG) mice were subjected to TAA treatment for 10 weeks (TAA-10w). (a) Representative images of liver sections were immunostained for 4-HNE and neutrophils. P, portal vein; C, central vein. (b) Liver tissues from WT and Cygb-TG mice were examined for immunoblotting for phosphorylated- and total NF-κB. The densitometric intensity of phosphorylated-NF-κB was quantified. GAPDH was used as the loading control and for normalization. Full-length Western blots in one gel are presented in Supplementary Fig. S10. (c) Hepatic mRNA levels of the attractant chemokines Ccl-2 and Nox-2 were determined by RT-qPCR (n = 9 to 10). (d) The average number of neutrophil-positive cells per square millimetre in liver sections from WT and TG mice was quantified (n = 5). Data are expressed as the mean ± SD. *p < 0.05, **p < 0.01, ***p < 0.001.