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. 2018 Dec 14;8:17860. doi: 10.1038/s41598-018-36215-4

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Overexpression of Cygb alleviated the ROS-induced activation of HSCs. DCFDA assay for HSCs^Cygb-WT treated with H₂O₂ in a dose-dependent manner (a), and comparison to HSCs^Cygb-TG at a specific concentration (10 μM) (b). RFU, relative fluorescence unit. (c) Immunoblot analysis of αSMA and CYGB in HSCs^Cygb-WT and HSCs^Cygb-TG under H₂O₂ exposure at different doses. Densitometric intensity was quantified. GAPDH was used as a loading control and for normalization. a, p ≤ 0.001 relative to non-treated HSCs^Cygb-WT; b, p ≤ 0.01 relative to non-treated HSCs^Cygb-TG; c, p ≤ 0.05 relative to non-treated HSCs^Cygb-TG. Full-length Western blots of one gel are presented in Supplementary Fig. S11. Values are given as the mean ± SD of all experiments. *p < 0.05, **p < 0.01, ***p < 0.001.