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. 2018 Dec 14;8:17863. doi: 10.1038/s41598-018-36078-9

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Female Ad-B2^(−/−) mice only develop moderate metabolic dysfunction when fed a high-fat diet at thermoneutrality. Five hour fasted blood glucose levels (A) and glucose tolerance test (B) at twenty-eight weeks of age in B2^(fl/fl), Ad-B2^(+/−) and Ad-B2^(−/−) mice housed at thermoneutrality and fed a high-fat diet for four weeks (n = 5–6). Five hour fasted circulating serum levels of insulin (C), glucose (D), triglyceride (E) and quantitative sensitivity check index analysis (F) in twenty-eight week old B2^(fl/fl), Ad-B2^(+/−) and Ad-B2^(−/−) female mice housed at thermoneutrality and fed a high-fat diet for four weeks (n = 5–6). (G) Liver triglyceride levels normalised to tissue weight in five hour fasted B2^(fl/fl), Ad-B2^(+/−) and Ad-B2^(−/−) mice housed at thermoneutrality and fed a high-fat diet for four weeks (n = 5–6). All data are presented as the mean ± SEM, *p < 0.05 vs B2^(fl/fl), ^#p < 0.05 vs Ad-B2^(+/−).