Table 2.

Risk of onychomycosis for each vascular disease and vice versa.

	3-year risk of each vascular disease in patients with OM	OR (95% CI)	P		3-year risk of OM in patients with vascular disease	OR (95% CI)	P
Hypertension
Controls	0.076% (62,276/818,743)	Reference		Controls	0.061% (49,120/802,664)	Reference
OM	0.071% (3,694/52,137)	0.926 (0.895–0.959)	<0.0001	Hypertension	0.069% (4,481/65 405)	1.128 (1.093–1.165)	<0.0001
Angina pectoris
Controls	0.024% (21,793/909,004)	Reference		Controls	0.07% (66,039/944,945)	Reference
OM	0.025% (1,643/67,124)	1.021 (0.971–1.075)	0.412	Angina pectoris	0.072% (1,642/22,834)	1.031 (0.980–1.085)	0.236
Cerebral infarction
Controls	0.015% (13,710/912,852)	Reference		Controls	0.071% (68,031/956,751)	Reference
OM	0.014% (958/68,709)	0.927 (0.868–0.991)	0.25	Cerebral infarction	0.063% (890/14,204)	0.873 (0.816–0.935)	<0.0001
Other peripheral vascular disease
Controls	0.033% (29,871/907,277)	Reference		Controls	0.069% (64,451/936,629)	Reference
OM	0.039% (2,587/65,978)	1.199 (1.151–1.249)	<0.0001	Peripheral vascular disease	0.077% (2,417/31,417)	1.128 (1.081–1.177)	<0.0001
Varicose veins
Controls	0.008% (7,747/919,540)	Reference		Controls	0.072% (69,313/969,680)	Reference
OM	0.01% (675/69,750)	1.150 (1.063–1.245)	0.001	Varicose veins	0.068% (552/8,079)	0.953 (0.873–1.039)	0.273
Hemorrhoids
Controls	0.048% (43,964/909,631)	Reference		Controls	0.07% (64,529/926,999)	Reference
OM	0.045% (2,950/66,335)	0.916 (0.882–0.952)	<0.0001	Hemorrhoids	0.059% (2,672/45,601)	0.832 (0.799–0.866)	<0.0001