Skip to main content
. 2018 Dec 14;8:279. doi: 10.1038/s41398-018-0309-1

Table 4.

Transporter, 5-HT1A and 5-HT2A binding in suicide and major depressive disorder in subjects with and without alcohol use disorder

Only alcoholic cases:
Receptor n Group BA 8 BA 9 BA 46 BA 45 BA 47 BA 11 BA 12 BA 32 BA 24
SERT 52 NonSuicide 5.56 ± 2.01 6.48 ± 2.59 7.02 ± 2.95 9.14 ± 5.55 9.51 ± 6.36 10.24 ± 5.87 11.56 ± 4.48 10.1 ± 3.89 24.32 ± 8.93
20 Suicide 5.54 ± 2.57 6.27 ± 2.75 6.36 ± 2.57 8.29 ± 4.06 10.2 ± 6.65 11.42 ± 8.29 9.3 ± 4.99 9.46 ± 5.37 21.81 ± 16.08
5-HT1A 49 NonSuicide 13.04 ± 4.43 14.6 ± 4.65 13.65 ± 3.79 14.59 ± 4.39 17.07 ± 5.51 18.9 ± 5.97 17.19 ± 5.37 15.29 ± 5.41 18.81 ± 7.44
20 Suicide 15.96 ± 3.38 16.15 ± 3.89 16.31 ± 3.34 15.6 ± 2.8 19.72 ± 4.46 22.18 ± 6.24 18.77 ± 4.96 17.53 ± 3.85 22.24 ± 4.73
5-HT2A 52 NonSuicide 26.31 ± 10.13 28.46 ± 11.36 29.77 ± 9.91 28.65 ± 9.76 32.01 ± 10.6 33.14 ± 10.84 33.43 ± 10.21 28.74 ± 9.93 21.84 ± 8.28
19 Suicide 38.94 ± 12.19 36.59 ± 12.73 38.32 ± 12.07 35.53 ± 10.59 39.52 ± 11.59 38.9 ± 10.53 38.84 ± 12 34.99 ± 11.33 30.2 ± 10.99
SERT 57 NoMDD 5.62 ± 2.08 6.49 ± 2.65 6.99 ± 2.88 9.18 ± 5.41 9.83 ± 6.59 10.75 ± 6.49 11.52 ± 4.73 10.39 ± 3.92 23.97 ± 10.57
14 MDD 5.35 ± 2.66 6.13 ± 2.68 6.12 ± 2.87 7.44 ± 3.88 9.12 ± 6.09 9.85 ± 7.55 8.13 ± 3.97 7.97 ± 5.54 19.91 ± 12.92
5-HT1A 55 NoMDD 13.33 ± 4.16 14.7 ± 4.43 14.15 ± 3.91 14.74 ± 4.17 17.42 ± 4.96 19.47 ± 5.63 17.41 ± 5.22 15.42 ± 4.98 18.97 ± 6.78
13 MDD 16.66 ± 4.52 16.53 ± 4.72 15.57 ± 3.61 15.65 ± 3.3 19.67 ± 6.71 21.51 ± 8.49 18.83 ± 5.74 18.24 ± 5.22 24.03 ± 6.03
5-HT2A 56 NoMDD 27.93 ± 12.35 29.78 ± 12.48 31.22 ± 11.23 29.54 ± 10.53 33.49 ± 11.81 34.32 ± 11.57 34.56 ± 11.52 29.74 ± 10.81 23.05 ± 9.42
14 MDD 36.21 ± 9.18 33.82 ± 11.3 35.97 ± 11.11 34.53 ± 9.52 36.68 ± 9.77 36.66 ± 8.93 36.97 ± 8.89 32.3 ± 10.01 26.92 ± 9.42
Only non-alcoholic cases
Receptor n Group BA 8 BA 9 BA 46 BA 45 BA 47 BA 11 BA 12 BA 32 BA 24
SERT 50 NonSuicide 5.82 ± 2.19 6.11 ± 2.59 6.45 ± 2.5 7.79 ± 3.17 8.49 ± 3.28 8.89 ± 3.38 10.41 ± 5.29 9.06 ± 4.42 21 ± 13.42
36 Suicide 4.07 ± 1.73 4.82 ± 2.42 4.97 ± 3.19 6.1 ± 3.2 6.9 ± 4.05 7.53 ± 4.67 7.66 ± 4.64 6.52 ± 3.51 12.83 ± 10.65
5-HT1A 51 NonSuicide 12.6 ± 3.16 13.44 ± 3.97 12.94 ± 3.9 13.57 ± 4.16 15.94 ± 5.11 17.11 ± 5.67 17.64 ± 6.48 14.37 ± 4.68 17.6 ± 5.59
37 Suicide 13.83 ± 4.22 14.19 ± 4.49 15.09 ± 4.72 15.03 ± 3.89 17.41 ± 4.85 18.84 ± 5.14 18.74 ± 4.82 15.27 ± 4.1 17.7 ± 5.98
5-HT2A 52 NonSuicide 28.25 ± 8.14 28.38 ± 9.39 28.61 ± 9.93 30.68 ± 10.47 32.2 ± 10.65 32.84 ± 11.83 32.55 ± 12.12 29.97 ± 8.76 26.72 ± 8.6
38 Suicide 26.92 ± 12.7 29.14 ± 13.43 30.39 ± 13 29.57 ± 12.48 32.96 ± 13.38 33.34 ± 13.83 31.88 ± 13.46 29.16 ± 13.21 18.85 ± 6.4
SERT 55 NoMDD 5.68 ± 2.17 6.16 ± 2.6 6.33 ± 2.53 7.64 ± 3.15 8.36 ± 3.31 8.81 ± 3.41 10.29 ± 5.15 8.86 ± 4.39 20.02 ± 13.28
31 MDD 4.04 ± 1.82 4.57 ± 2.26 4.93 ± 3.3 6.15 ± 3.32 6.97 ± 4.14 7.48 ± 4.8 7.48 ± 4.82 6.52 ± 3.54 13.49 ± 11.53
5-HT1A 55 NoMDD 12.71 ± 3.14 13.58 ± 3.97 13.22 ± 3.94 13.87 ± 4.01 16.37 ± 5.1 17.58 ± 5.46 17.91 ± 6.38 14.66 ± 4.6 17.53 ± 5.42
33 MDD 13.81 ± 4.48 14.05 ± 4.58 14.87 ± 4.91 14.69 ± 4.27 16.86 ± 4.96 18.21 ± 5.62 18.39 ± 4.91 14.86 ± 4.24 17.91 ± 6.43
5-HT2A 56 NoMDD 28.1 ± 8.47 28.26 ± 9.63 28.42 ± 10.03 30.41 ± 10.36 32.06 ± 10.68 32.76 ± 11.83 32.14 ± 12.13 29.51 ± 8.82 26.36 ± 8.56
34 MDD 27.03 ± 12.85 29.44 ± 13.54 30.93 ± 13.16 29.9 ± 12.92 33.27 ± 13.57 33.54 ± 14.02 32.52 ± 13.6 29.89 ± 13.53 17.7 ± 5.63

Values are expressed as fmol/mg tissue, mean ± SD

BA Brodmann area, MDD major depressive disorder, SERT serotonin transporter