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. 2018 Apr 17;26(1):162–178. doi: 10.1038/s41418-018-0108-5

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — The number of cell corpses within the gonad is reduced in the cisd animals with disrupted ced-13 function. Using the ACT-5::YFP reporter strain to visualize apoptotic cells, the number of apoptotic cells was quantified in the cisd-1(tm4993), cisd-3.1(RNAi) and cisd-3.2(RNAi) animals with ced-13 knock-down. a Representative images of the gonad arm of control, cisd-1(tm4993), cisd-3.1(RNAi), and cisd-3.2(RNAi) animals with or without knock-down of ced-13 by RNAi. The ACT-5::YFP reporter is shown individually and merged with the DIC image. White arrows point to apoptotic cells within the gonad. Scale bar = 20 µm. b Disruption of ced-13 function by RNAi reduced the number of cell death corpses within the gonad of the cisd-1(tm4993), cisd-3.1(RNAi), cisd-3.2(RNAi) animals. Identical letters indicate groups with no significant differences; different letters indicate P < 0.0001 (Kruskal–Wallis, Dunn’s multiple comparison test). The number of apoptotic corpses within the gonad were quantified in animals from three independent experiments for a total of at least thirty animals. Error bar represents standard deviation.