Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Dec 6;62:10.29219/fnr.v62.1493. doi: 10.29219/fnr.v62.1493

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2018 Xiujing Dou et al.

This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 International License, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material for any purpose, even commercially, provided the original work is properly cited and states its license.

PMC Copyright notice

Fig. 7 — The signaling pathway of defensins and interleukins gene expression is regulated by PBA in porcine intestinal epithelial cells. Sodium phenyl butyrate (PBA) activated the NF-κB pathway via the phosphorylation of p65 and IκB α synthesis delayed and degraded. TLR2, TLR4, and EGFR were required for the PBA-mediated up-regulation of the HDPs. Meanwhile, histone deacetylase (HDAC) inhibition and an increased phosphorylation of histone H3 on serine S10 also occurred in PBA-induced HDP expression independently on TLR2 and TLR4. Furthermore, p38-MAPK suppressed PBA-induced pEP2C, pBD-1, pBD-3, IL-8, and IL-18 expression, and ERK1/2 abolished the regulation of pEP2C and pBD-1. In conclusion, HDPs and interleukins expression were regulated by PBA via a complex route system.