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DkTx produces a robust activation of TRPV1 lacking the pore turret. (A) DkTx-induced withdrawal responses of worms expressing rTRPV1 or TRPV1Δ23. Bars represent mean ± SEM, ***P ≤ 0.001 (Mann–Whitney U rank tests were used for statistical analysis). (B) Capsaicin-induced withdrawal response of worms expressing rTRPV1 or TRPV1Δ23. Bars represent mean ± SEM, ***P ≤ 0.001 (Mann–Whitney U rank tests were used for statistical analysis).
