Fig. 5.

iHCC subgroups rely on alternative enzymes catalyzing the same reactions and display specific synthetic lethal genes. (A) Flux balance analysis performed on iHCC-specific models shows that iHCC1 or iHCC3 displays the highest reaction fluxes, followed by iHCC2. The predominant color in each box shows the iHCC subtype that displays the highest flux. (B) Metabolic genes involved in transport, glycolysis, and the TCA colored according to expression in each subgroup. (C) Numbers of synthetic lethal genes found in iHCC subgroups are shown, highlighting five synthetic lethal genes per subgroup. No synthetic lethal genes are simultaneously identified in iHCC1 and iHCC3, but several are found between iHCC2 and the other subgroups.