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. 2018 Nov 27;115(50):12751–12756. doi: 10.1073/pnas.1816495115

Fig. 1.

Fig. 1.

Snapshots of ND-bilayer fusion showing key intermediates observed in Sim1. (A) Initial, energy-minimized structure. The ND is shown in orange, and the bilayer is shown in tan. (B) Snapshot after 10 ns of equilibration showing formation of a “dimple” in the bilayer. (C) Zoom-in view (at 239 ns) showing the association of three splayed lipids highlighted in a ball-and-stick representation, two (green and cyan) from the ND and one (magenta) from the bilayer. (D) Expansion of hydrophobic core to from the stalk (at 245 ns). (E) Evolved pore (1 μs). Waters are shown as cyan spheres. (F) Pore closure at 2.1 μs.