Figure 1: Tissue fibrosis and associated diseases.

Tissue fibrosis is a major cause of death worldwide due to organ failure as several chronic diseases are associated with severe fibrosis leading to organ failure due to impairment in the regulation of inflammation, metabolic pathways and infections. Monogenic mutations could lead to malformed proteins which can manifest into impaired tissue remodeling and fibrosis in chronic diseases such as Cystic Fibrosis (CF), Duchenne Muscular Dystrophy (DMD) and familial interstitial lung diseases (fILD).