Table 2.

The evidence of the four differential proteins on IgAN or kidney injury in tissue level, body fluid level and functional level

Protein name	Kidney tissue evidence on IgAN	Kidney tissue evidence on IgAN method	Body floid evidence on IgAN	Body floid evidence on IgAN method	Evidence in kidney injury and other kidney diease
ADIPOQ			serum ↑ urinary↑ [35]	radio-immunity analysis	1. an adipocyte-specific plasma protein 2. accumulates in the injured kidney, modulating inflammation and oxidative stress. [25, 26] 3. induces kidney apoptosis in Ischemia-reperfusion injury [27].
SERPINC1	capillary walls of the glomeruli [24]	immunofluorescence	urinary↑ [10, 24]	Laurell rocket immunoelectrophoresis; iTRAQ quantification	1. Serine protease inhibitors in plasma that inhibits the blood coagulation cascade.
ICAM1	The tubular and interstitial expression [30]	avidin-biotin-peroxidase			1. a member of ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). 2. Increases in acute renal allograft rejection [31], chronic kidney disease (CKD) [32] and lupus nephritis [33, 34] in urine.
TIMP1					1. A positive regulator of ECMs in the mesangium. 2. Elevated in acute kidney injury (AKI) after liver transplantation [28] 3. Overexpressed in the kidney tissue of diabetic nephropathy rats [29].