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. 2018 Dec 14;13:319. doi: 10.1186/s13018-018-1019-3

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 7 — MiRNA–mRNA regulatory networks in surgical-induced rat OA model. a MiRNA–mRNA (Itga8, Col1a1, Col12a1, Col4a1, Ccl7, Mmp12, and Ccl2) regulatory networks. Red nodes denote genes from sub-networks and purple nodes denote miRNAs; red edges denote mRNAs-mRNAs interaction relationship and blue edges denote miRNAs-mRNAs interaction relationship. b Bubble graph for KEGG pathway enrichment analysis of predicted miRNAs