Table 2.
Recombinant FIPs produced in Pichia pastoris
| FIPs | Pichia strains | Vectors | Yields (mg L− 1) |
Bioactivities | References |
|---|---|---|---|---|---|
| LZ-8 | GS115 | pPIC-9 | 191.2 | hemagglutination, mitogenesis, IL-2 induction, anti-tumor | Lin et al., 2009 |
| GS115 | pPIC-9 K | 270 | hemagglutination, mitogenesis | Xue et al., 2008 | |
| X-33 | pPICZαA | 350 | not mentioned | Bastiaan et al., 2013 | |
| X-33 | pPICZαA | 34.4 | hemagglutination | Song et al., 2011 | |
| GS115 | pPIC-9 | 253.6 | hemagglutination, mitogenesis, IL-2& IFN-γ induction, anti-tumor | Current study | |
| FIP-fve | GS115 | pPIC-9 | 158.2 | hemagglutination, mitogenesis, IL-2 & IFN-γ induction | Lin et al., 2013 |
| X-33 | pPICZαA | 18.9 | hemagglutination | Bastiaan et al., 2013 | |
| FIP-vvo | X-33 | pPICZαA | 410 | hemagglutination, mitogenesis, IFN-γ induction | Sun et al.,2014 |
| FIP-nha | X-33 | pPICZαA | 42.7 | hemagglutination | Bastiaan et al., 2013 |
| FIP-cru | GS115 | pPIC-9 | 148.5 | hemagglutination, mitogenesis, IL-2 induction | Lin et al., 2016 |
| LZ-9 | X-33 | pPICZαA | 6.7 | hemagglutination | Bastiaan et al., 2013 |
| FIP-gsi | GS115 | pPIC-9 | 264.3 | hemagglutination, mitogenesis, IL-2& IFN-γ induction, anti-tumor | Current study |
| FIP-gap1 | GS115 | pPIC-9 | 247.4 | hemagglutination, mitogenesis, IL-2& IFN-γ induction, anti-tumor | Current study |
| FIP-gap2 | GS115 | pPIC-9 | 197.5 | hemagglutination, mitogenesis, IL-2& IFN-γ induction, anti-tumor | Current study |
LZ-8, FIP-fve, FIP-vvo, FIP-nha, FIP-cru, LZ-9, FIP-gsi, FIP-gap1 and FIP-gap2 represent FIPs from G. lucidum, Flammulina velutipes, Volvariella volvacea, Nectria haematococca, Chroogomphis rutilus, G. lucidum, G. sinense and G. applanatum