Table 2.
Comparison of genotype and allele frequency of Klotho C1818T among the four groups
| Groups SNPs |
(1) H-Tens (N = 60) |
(2) CAD + H-Tens (N = 95) |
(3) CAD (N = 61) |
(4) Ctrl (N = 70) |
P-value | ||||
|---|---|---|---|---|---|---|---|---|---|
| 1 vs. 4 | 2 vs. 4 | 3 vs. 4 | 1&2&3&4 | ||||||
| C1818T (rs564481) Total Subjects | |||||||||
| CC | 23 (38%) | 53 (56%) | 21 (34%) | 33 (47%) | 0.50 | 0.27 | 0.33 | 0.13 | |
| CT | 31 (52%) | 37 (39%) | 32 (52%) | 29 (41%) | |||||
| TT | 6 (10%) | 5 (5%) | 8 (13%) | 8 (11%) | |||||
| Allele C | 77 (64%) | 143 (75%) | 74 (61%) | 95 (68%) | 0.45 | 0.14 | 0.22 | 0.03* | |
| Allele T | 43 (36%) | 47 (25%) | 48 (39%) | 45 (32%) | |||||
| HWE | X2 | 0.92 | 0.2 | 0.6 | 0.18 | ||||
| P-value | 0.41 | 0.79 | 0.59 | 0.78 | |||||
| C1818T (rs564481) Age < 57 years | |||||||||
| CC | 14 (41%) | 26 (62%) | 11 (42%) | 25 (58%) | 0.28 | 0.39 | 0.42 | 0.28 | |
| CT | 17 (50%) | 15 (36%) | 11 (42%) | 14 (33%) | |||||
| TT | 3 (9%) | 2 (2%) | 4 (15%) | 4 (9%) | |||||
| Allele C | 45 (66%) | 67 (80%) | 33 (63%) | 64 (74%) | 0.30 | 0.39 | 0.19 | 0.10 | |
| Allele T | 23 (34%) | 17 (20%) | 19 (37%) | 22 (26%) | |||||
| HWE | X2 | 0.46 | 0.47 | 0.20 | 0.90 | ||||
| P-value | 0.71 | 0.99 | 0.68 | 0.42 | |||||
| C1818T (rs564481) Age ≥ 57 years | |||||||||
| CC | 9 (35%) | 27 (51%) | 10 (29%) | 8 (30%) | 0.89 | 0.16 | 0.90 | 0.39 | |
| CT | 14 (54%) | 23 (43%) | 21 (60%) | 15 (56%) | |||||
| TT | 3 (12%) | 3 (6%) | 4 (11%) | 4 (15%) | |||||
| Allele C | 32 (62%) | 77 (72%) | 40 (59%) | 31 (57%) | 0.81 | 0.10 | 0.98 | 0.22 | |
| Allele T | 20 (38%) | 29 (28%) | 28 (41%) | 23 (43%) | |||||
| HWE | X2 | 0.49 | 0.02 | 1.95 | 0.49 | ||||
| P-value | 0.69 | 0.89 | 0.29 | 0.70 | |||||
(1): H-Tens = Hypertension; (2): CAD + H-Tens = Coronary artery disease and hypertension; (3): CAD = Coronary artery disease; (4): Ctrl = Control. Values are presented as number (percentage). Genotypes and allele frequencies were compared among groups using chi-square/Fisher’s exact tests. *Significant difference (P<0.05)