Table 3.
DMRs associated with the rs12150660 SHBG polymorphism
| Differentially methylated region (DMR) | N CpGs | Ŝidak p-value | Gene | Rangea | |
|---|---|---|---|---|---|
| SHBG genotype | |||||
| Childhood | |||||
| Females | Chr2:202901045–202901471 | 5 | 1.9E-03 | FZD7 | 0.026, 0.046 |
| Females | Chr12:130060028–130060081 | 2 | 9.9E-03 | TMEM132D | 0.009, 0.018 |
| Adolescence | |||||
| Females | Chr11:67418045–67418406 | 10 | 7.8E-06 | ACY3;SMAD3 | −0.024, −0.0036 |
aRange of effect sizes observed across CpGs comprising that DMR, where estimates are change in methylation beta per copy of rs12150660 variant allele