Table 2:
Sensitivity analyses examining associations of HCV with select cancers
| Cancer | Excluding HBV and HIV infected individuals |
Never alcohol abusers | Non-cirrhotics | Additional adjustment for median household income |
||||
|---|---|---|---|---|---|---|---|---|
| aOR* (95% CI) | p value | aOR* (95% CI) | p value | aOR* (95% CI) | p value | aOR*† (95% CI) | p value | |
| Anus | 1.65 (1.09, 2.50) | 0.0173 | 1.59 (1.05, 2.40) | 0.0277 | 1.77 (1.22, 2.56) | 0.0027 | 1.97 (1.42, 2.73) | < 0.0001 |
| Liver | 32.2 (29.1, 35.5) | < 0.0001 | 32.5 (29.5, 35.7) | < 0.0001 | 23.8 (21.6, 26.2) | < 0.0001 | 31.6 (29.0, 34.3) | < 0.0001 |
| Intrahepatic bile duct | 2.99 (2.05, 4.34) | < 0.0001 | 3.11 (2.20, 4.40) | < 0.0001 | 2.99 (2.12, 4.20) | < 0.0001 | 3.38 (2.51, 4.56) | < 0.0001 |
| Extrahepatic bile duct | 2.06 (1.46, 2.90) | < 0.0001 | 1.99 (1.43, 2.76) | < 0.0001 | 1.92 (1.39, 2.64) | 0.0001 | 1.91 (1.41, 2.58) | < 0.0001 |
| Pancreas | 1.28 (1.11, 1.49) | 0.0009 | 1.24 (1.08, 1.44) | 0.0030 | 1.27 (1.11, 1.46) | 0.0005 | 1.23 (1.09, 1.40) | 0.0012 |
| Non-epithelial skin | 1.78 (1.31, 2.43) | 0.0002 | 1.67 (1.23, 2.26) | 0.0010 | 1.59 (1.18, 2.16) | 0.0027 | 1.54 (1.15, 2.04) | 0.0033 |
| Uterus | 0.66 (0.51, 0.86) | 0.0016 | 0.61 (0.48, 0.77) | 0.0001 | 0.62 (0.48, 0.79) | 0.0001 | 0.64 (0.51, 0.80) | 0.0001 |
| Prostate† | 0.73 (0.66, 0.82) | < 0.0001 | 0.76 (0.67, 0.87) | < 0.0001 | 0.77 (0.68, 0.86) | < 0.0001 | 0.73 (0.66, 0.82) | < 0.0001 |
| MDS | 1.56 (1.30, 1.88) | < 0.0001 | 1.64 (1.37, 1.96) | < 0.0001 | 1.43 (1.19, 1.70) | 0.0001 | 1.56 (1.33, 1.83) | < 0.0001 |
| DLBCL | 1.55 (1.29, 1.87) | < 0.0001 | 1.74 (1.46, 2.06) | < 0.0001 | 1.55 (1.30, 1.84) | < 0.0001 | 1.57 (1.33, 1.84) | < 0.0001 |
Abbreviations: aOR, adjusted odds ratio; CI, confidence intervals; DLBCL, diffuse large B-cell lymphoma; HBV, hepatitis B virus; HIV, human immunodeficiency virus; MDS, myelodysplastic syndrome
Odds ratios assess the association of HCV with the specified cancer and were adjusted for age categories (65-69, 70-74, 75-79, 80-84, 85+ years), sex, race/ethnicity, calendar year of cancer diagnosis/control selection (1993-1999, 2000-2003, 2004-2007, 2008-2011), number of physician claims per year (< 2.56, 2.56 to < 5.57, 5.57 to < 10.07, 10.07+), and smoking status (never/ever)
Odds ratios assess the association of HCV with the specified cancer and were adjusted additionally for the zip code median household income categories (< 35,097, 35,097-45,537, 45,538-59,164, and 59,165+ US dollars). Models were separately adjusted for the education and poverty variables shown in Table 1, instead of median household income, with a resulting change in point estimates by <10% for all cancers (not shown).