Table 3.
Factors associated with endometrial Mycloplasma genitalium infection
| Risk factor* | Cervix only n=20 |
Endometrial n=19 |
RR (95%CI) | P values | RRadj (95%CI)† | P values |
|---|---|---|---|---|---|---|
| Demographics and behaviour | ||||||
| Age‡ | 21±3.1 | 21±2.4 | 1.0 (0.9 to 1.1) | 0.85 | NA | NA |
| Non-black race | 9 (45.0) | 3 (15.8) | 0.4 (0.2 to 1.2) | 0.10 | 0.7 (0.3 to 1.4)§ | 0.31 |
| Uninsured | Reference | Reference | Reference | |||
| Private insurance | 2 (10.0) | 3 (15.7) | 0.9 (0.4 to 2.1) | 0.89 | NA | NA |
| Medicaid | 12 (60.0) | 11 (57.9) | 1.2 (0.5 to 2.8) | 0.57 | NA | NA |
| Posthigh school education | Reference | Reference | Reference | NA | NA | |
| <High school education | 4 (20.0) | 5 (26.3) | 1.0 (0.5 to 2.6) | 0.96 | NA | NA |
| High school education | 9 (45.0) | 8 (42.1) | 1.2 (0.5 to 2.6) | 0.66 | ||
| Married | 2 (10.0) | 2 (10.5) | 1.0 (0.4 to 2.9) | 0.97 | NA | NA |
| Non-smoker | 10 (50.0) | 5 (26.3) | 0.6 (0.3 to 1.3) | 0.16 | 0.7 (0.4 to 1.4)§ | 0.34 |
| Drug user | 5 (25.0) | 9 (47.4) | 1.6 (0.9 to 3.0) | 0.13 | 1.0 (0.4 to 2.5)¶ | 0.97 |
| Douching | 9 (45.0) | 9 (47.3) | 1.1 (0.5 to 1.9) | 0.88 | NA | NA |
| Reproductive history, sexual activity and contraception | ||||||
| History of Chlamydia trachomatis | 11 (55.0) | 5 (26.3) | 0.5 (0.2 to 1.1) | 0.10 | 0.8(0.4 to 1.7)¶ | 0.59 |
| History of Neisseria gonorrhoeae | 7 (35.0) | 4 (21.0) | 0.7 (0.3 to 1.6) | 0.37 | NA | NA |
| History of Trichomonas vaginalis | 4 (20.0) | 2 (10.5) | 0.5 (0.1 to 3.1) | 0.48 | NA | NA |
| History of BV | 10 (50.0) | 7 (36.8) | 0.6 (0.2 to 2.2) | 0.43 | NA | NA |
| Female partner | 3 (15.0) | 6 (31.5) | 1.6 (0.9 to 3.0) | 0.11 | 1.2 (0.6 to 2.2)¶ | 0.60 |
| Infected partner | 6 (30.0) | 5 (26.3) | 0.8 (0.2 to 3.4) | 0.81 | NA | NA |
| Multiple partners | 3 (15.0) | 3 (16.7) | 1.1 (0.2 to 6.0) | 0.94 | NA | NA |
| New partner 30d | 5 (25.0) | 4 (21.1) | 0.8 (0.2 to 3.7) | 0.79 | NA | NA |
| Oral sex | 15 (65.2) | 10 (52.6) | 0.6 (0.3 to 1.2) | 0.13 | 0.6 (0.3 to 0.9)§ | 0.04 |
| Consistent condom use | Reference | Reference | Reference | NA | NA | |
| Rarely/never use condoms | 5 (25.0) | 3 (16.7) | 0.5 (0.1 to 2.5) | 0.38 | ||
| Inconsistent condom use | 7 (35.0) | 5 (26.3) | 0.5 (0.1 to 2.3) | 0.41 | ||
| Depo-Provera injections | 3 (15.0) | 4 (21.1) | 1.2 (0.6 to 2.5) | 0.59 | NA | NA |
| Withdrawal | 8 (40.0) | 6 (31.5) | 0.7 (0.2 to 2.6) | 0.61 | NA | NA |
| None | 3 (15.0) | 3 (16.7) | 1.1 (0.2 to 6.0) | 0.95 | NA | NA |
| Microbiology | ||||||
| C. trachomatis | ||||||
| None | Reference | Reference | Reference | |||
| Cervical | 16 (80.0) | 13 (68.4) | 0.7 (0.4 to 1.4) | 0.38 | NA | NA |
| Endometrial | 2 (10.0) | 8 (42.1) | 2.1 (1.2 to 3.7) | 0.009 | 1.7(1.1 to 2.8)§ | 0.02 |
| N. gonorrhoeae | 3 (15.0) | 2 (11.1) | 0.7 (0.1 to 4.8) | 0.73 | NA | NA |
| BV | 15 (75.0) | 13 (68.4) | 2.8 (0.6 to 12.3) | 0.17 | 1.5 (0.7 to 2.8)¶ | 0.27 |
| T. vaginalis | 2 (10.0) | 8 (42.1) | 2.1 (1.2 to 3.7) | 0.009 | 2.0 (1.2 to 3.4)§ | 0.01 |
| High bacterial burden** | 10 (50.0) | 16 (84.2) | 2.4 (0.9 to 6.8) | 0.08 | 2.3 (1.0 to 5.2)§ | 0.05 |
*
Factors with cell size <2 were not analysed. This included some contraception methods (pills and IUD) and sexual activity variables (uncircumcised partner, anal sex, etc and so on).
†
P≤0.2 in univariable analyses were tested in the multivariable analysis, where variables with a P≤0.1 were retained.
‡
Age is a continuous variable, values listed in table are mean±SD. All others are binary or categorical and listed as n (%).
§
Included in final model.
¶
Not retained in the final model.
**
High burden >104 DNA copies/swab.
BV, bacterial vaginosis; IUD, intrauterine device.