Table 1.
Baseline characteristics at visit 4 according to CKD status, ARIC, 1996–1998
| eGFR (mL/min/1.73 m2) | ACR (mg/g) | |||||
|---|---|---|---|---|---|---|
| ≥60 | <60 | p-value | <30 | ≥30 | p-value | |
| Number | 9,522 | 1,202 | 9,837 | 887 | ||
| Age, years (SD) | 63 (6) | 67 (5) | <0.001 | 63 (6) | 65 (6) | <0.001 |
| Black, % | 2136 (22%) | 228 (19%) | 0.006 | 2028 (21%) | 336 (38%) | <0.001 |
| Female, % | 5338 (56%) | 687 (57%) | 0.471 | 5556 (56%) | 469 (53%) | 0.038 |
| Center, % | <0.001 | <0.001 | ||||
| Forsyth County, NC | 2343 (25%) | 303 (25%) | 2482 (25%) | 164 (18%) | ||
| Jackson, MS | 1887 (20%) | 200 (17%) | 1784 (18%) | 303 (34%) | ||
| Suburban Minneapolis, MN | 2780 (29%) | 302 (25%) | 2912 (30%) | 170 (19%) | ||
| Washington County, MD | 2512 (26%) | 397 (33%) | 2659 (27%) | 250 (28%) | ||
| Smoking status, % | 0.611 | <0.001 | ||||
| Non-smoker | 3968 (42%) | 483 (40%) | 4128 (42%) | 323 (36%) | ||
| Former smoker | 4143 (43%) | 535 (45%) | 4304 (44%) | 374 (42%) | ||
| Current smoker | 1411 (15%) | 184 (15%) | 1405 (14%) | 190 (21%) | ||
| Drinking status, % | <0.001 | <0.001 | ||||
| Non-drinker | 1900 (20%) | 308 (26%) | 1987 (20%) | 221 (25%) | ||
| Former drinker | 2782 (29%) | 420 (35%) | 2879 (29%) | 323 (36%) | ||
| Current drinker | 4840 (51%) | 474 (40%) | 4971 (51%) | 343 (39%) | ||
| Anti-HTN medication, % | 3810 (40%) | 818 (68%) | <0.001 | 3992 (41%) | 636 (72%) | <0.001 |
| Diabetes, % | 1486 (16%) | 288 (24%) | <0.001 | 1387 (14%) | 387 (44%) | <0.001 |
| Prevalent stroke, % | 173 (2%) | 58 (5%) | <0.001 | 184 (2%) | 47 (5%) | <0.001 |
| Prevalent HF, % | 426 (4%) | 145 (12%) | <0.001 | 442 (4%) | 129 (15%) | <0.001 |
| Prevalent CHD, % | 700 (7%) | 182 (15%) | <0.001 | 722 (7%) | 160 (18%) | <0.001 |
| BMI, kg/m2 (SD) | 29 (6) | 30 (6) | <0.001 | 29 (6) | 30 (6) | <0.001 |
| SBP, mmHg (SD) | 127 (19) | 131(22) | <0.001 | 126 (18) | 141 (23) | <0.001 |
| DBP, mmHg (SD) | 71 (10) | 70 (11) | <0.001 | 71 (10) | 74 (12) | <0.001 |
| HDL cholesterol, mmol/L (SD) | 1.3 (0.4) | 1.2 (0.4) | <0.001 | 1.3 (0.4) | 1.2 (0.5) | 0.001 |
| Total cholesterol, mmol/L (SD) | 5.2 (0.9) | 5.2 (1.0) | 5.2 (0.9) | 5.2 (1.1) | 0.828 | |
| eGFR, mL/min/1.73 m2 (SD) | 82 (12) | 49 (10) | <0.001 | 79 (15) | 70 (23) | <0.001 |
| ACR, mg/g [IQI] | 3.6 [1.7–7.3] | 5.1 [2.3–19.5] | <0.001 | 3.3 [1.6–6.3] | 83.9 [46.4–252.1] | <0.001 |
| Incident AAA, % | 280 (3%) | 67 (6%) | <0.001 | 302 (3%) | 45 (5%) | 0.001 |
Values are mean (SD), n (%), or median [interquartile interval, IQI]. CKD: chronic kidney disease, CHD: coronary heart disease, HF: heart failure, BMI: body mass index, BP: blood pressure, HDL: high density lipoprotein, eGFR: estimated glomerular filtration rate, ACR: urine albumin-to-creatinine ratio, AAA: abdominal aortic aneurysm.