Table 1.
Proteins identified by mass spectrometry with significantly changed expression in anterior lobe of prostate tissue from Pten;Camkk2 vs Pten mice. Down-regulated in Pten;Camkk2 vs Pten Up-regulated in Pten;Camkk2 vs Pten mice.
| Down-regulated in Pten;Camkk2 vs Pten | ||
|---|---|---|
| Protein ID | Fold change | P-value |
| Abcf2 | >10 | 0.0027 |
| Fam98b | >10 | 0.0036 |
| Vps25 | >10 | 0.0053 |
| Cyb5b | >10 | 0.0079 |
| Egf | >10 | 0.0087 |
| Tial1 | >10 | 0.0098 |
| Hnrnpll | >10 | 0.0124 |
| Apmap | >10 | 0.0174 |
| Gsdma | >10 | 0.0182 |
| Gcat | >10 | 0.0268 |
| Atp5j2 | 7.56 | 0.0196 |
| Vdac2 | 6.08 | 0.0428 |
| Ly6c1 | 5.33 | 0.0424 |
| Usp9x | 4.77 | 0.0443 |
| Eif4a2 | 3.52 | 0.0368 |
| Gne | 3.49 | 0.0013 |
| Papss2 | 3.01 | 0.0058 |
| Eif3c | 2.99 | 0.0019 |
| Eif3e | 2.97 | 0.0019 |
| Dync1li2 | 2.91 | 0.0025 |
| Copg1 | 2.83 | 0.0099 |
| Eif4a1 | 2.82 | 0.0099 |
| Golph3 | 2.77 | 0.0095 |
| Fkbp5 | 2.77 | 0.0071 |
| Fasn | 2.76 | 0.0122 |
| Eif3a | 2.64 | 0.0114 |
| Hsp90ab1 | 2.52 | 0.0106 |
| Prkag1 | 2.46 | 0.0048 |
| Cox4i1 | 2.45 | 0.0328 |
| Vars | 2.43 | 0.0344 |
| Tmed7 | 2.40 | 0.0221 |
| Cyfip1 | 2.35 | 0.0388 |
| Hsp90aa1 | 2.34 | 0.0141 |
| Hsp90b1 | 2.34 | 0.0065 |
| Sec23b | 2.29 | 0.0266 |
| Stat1 | 2.23 | 0.0328 |
| Ddx3x | 2.21 | 0.0055 |
| Tmed2 | 2.20 | 0.0040 |
| Sec31a | 2.18 | 0.0123 |
| Asna1 | 2.18 | 0.0011 |
| Dnajc10 | 2.17 | 0.0273 |
| Ube2k | 2.14 | 0.0043 |
| Qars | 2.12 | 0.0216 |
| Gstm7 | 2.10 | 0.0210 |
| Cox6b1 | 2.09 | 0.0484 |
| Bpnt1 | 2.07 | 0.0164 |
| Pdia6 | 2.07 | 0.0055 |
| Papss1 | 2.06 | 0.0017 |
| Kpnb1 | 2.03 | 0.0065 |
| Apoa2 | 2.03 | 0.0469 |
| Dync1li1 | 2.03 | 0.0041 |
| Up-regulated in Pten;Camkk2 vs Pten | ||
|---|---|---|
| Protein ID | Fold change | P-value |
| Pklr | >10 | 0.0002 |
| Aif1 | >10 | 0.0002 |
| Wdr77 | >10 | 0.0077 |
| Endod1 | >10 | 0.0079 |
| H2afy | >10 | 0.0128 |
| Mycbp | >10 | 0.0146 |
| Cadm1 | >10 | 0.0220 |
| Pqbp1 | >10 | 0.0304 |
| Dbn1 | 6.84 | 0.0116 |
| Pvrl2 | 4.89 | 0.0392 |
| Lin7c | 4.84 | 0.0405 |
| Hspa1b | 4.61 | 0.0476 |
| F11r | 4.30 | 0.0136 |
| Hist1h1e | 2.59 | 0.0163 |
| Lmnb1 | 2.56 | 0.0437 |
| H1f0 | 2.54 | 0.0121 |
| Clca1 | 2.34 | 0.0238 |
| H2afv | 2.20 | 0.0406 |
| S100a16 | 2.09 | 0.0444 |
| Ltbp2 | 2.09 | 0.0044 |
| Hist1h1d | 2.06 | 0.0361 |
| Fbl | 2.02 | 0.0233 |
| Mpst | 2.02 | 0.0340 |
Protein lysates from the anterior prostate lobes of three independent animals per genotype aged 17 weeks were analysed in duplicated. Proteins with a fold change >2 and P<0.05 were determined to be significantly changed. Fasn is highlighted in grey and eukaryotic translation initiation factors in bold text.