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. Author manuscript; available in PMC: 2019 Dec 15.
Published in final edited form as: Clin Cancer Res. 2018 Aug 14;24(24):6556–6569. doi: 10.1158/1078-0432.CCR-17-1679

Figure 6. KMT2C/MLL3 re-expression in gastric cancer organoids.

Figure 6.

(A) Size of organoids formed from ACKPY3077 and ACKPY3944 organoids following stable transduction of CD44(+) cells with control lentiviral vector (Vector) or MLL3 lentiviral vector (MLL3). (B) Western blot demonstrating levels of MLL3, CD44, and EMT-related proteins (B) and self-renewal proteins (C) in ACKPY3077 and ACKPY3944 organoids following stable transduction of CD44(+) cells with control lentiviral vector (Vector) or MLL3 lentiviral vector (MLL3). (D) Photos and graph of number of spheroids formed from ACKPY3077 and ACKPY3944 organoids. (E) Tumor volume of flank xenografts from ACKPY3077 organoids. (F) Gross photos of flank xenografts and microscopic photo leading edge of tumors.