Table 1.
Characteristic | Survivors with subsequent BC |
Survivors without subsequent BC |
---|---|---|
N (%) | N (%) | |
Total | 47 | 1086 |
Race | ||
Non-Hispanic White | 47 (100%) | 1069 (98%) |
Hispanic White | 0 (0%) | 13 (1%) |
Other | 0 (0%) | 4 (0%) |
Diagnosis | ||
Leukemia | ||
Acute lymphoblastic leukemia | 3 (6%) | 389 (36%) |
Acute myeloid leukemia | 2 (4%) | 34 (3%) |
Other leukemia | 0 (0%) | 1 (0%) |
CNS tumors | ||
Astrocytoma or glioma | 1 (2%) | 58 (5%) |
Medulloblastoma or PNET | 0 (0%) | 22 (2%) |
Ependymoma | 0 (0%) | 12 (1%) |
Other | 0 (0%) | 21 (2%) |
Lymphoma | ||
Hodgkin lymphoma | 30 (64%) | 119 (11%) |
Non-Hodgkin lymphoma | 4 (9%) | 52 (5%) |
Sarcoma | ||
Ewing sarcoma | 0 (0%) | 36 (3%) |
Osteosarcoma | 1 (2%) | 37 (3%) |
Rhabdomyosarcoma | 0 (0%) | 29 (3%) |
Non-rhabdomyosarcoma | 2 (4%) | 33 (3%) |
Embryonal | ||
Wilms tumor | 2 (4%) | 89 (8%) |
Neuroblastoma | 0 (0%) | 60 (6%) |
Germ cell tumor | 1 (2%) | 25 (2%) |
Other | ||
Retinoblastoma | 0 (0%) | 28 (3%) |
Hepatoblastoma | 0 (0%) | 6 (1%) |
Melanoma | 0 (0%) | 5 (0%) |
Carcinomas | 1 (2%) | 15 (1%) |
Other | 0 (0%) | 15 (1%) |
Radiation (%) | ||
Any | 40 (85%) | 606 (56%) |
Cranial radiation therapy | 5 (11%) | 345 (32%) |
Breast | 36 (77%) | 149 (14%) |
Pelvis | 10 (21%) | 187 (17%) |
Chemotherapy | ||
Alkylating agent | 30 (64%) | 597 (55%) |
Anthracyclines | 27 (57%) | 636 (59%) |
Epipodophyllotoxins | 8 (17%) | 408 (38%) |
Mercaptopurine | 5 (11%) | 436 (40%) |
Methotrexate | 12 (26%) | 548 (50%) |
Platinum agents | 2 (4%) | 120 (11%) |
Vinca alkaloids | 34 (72%) | 795 (73%) |
Corticosteroids | 17 (36%) | 529 (49%) |
Median (range) | Median (range) | |
Age at diagnosis (years) | 15.2 (3.1–21.2) | 6.1 (0.01–22.7) |
Age at follow-up (years) | 44.5 (24.9–61.1) | 35.0 (8.4–67.4) |
Length of follow-up (years) | 31.2 (13.4–51.2) | 28.1 (5.6–53.5) |