Table 4.

Age-specific Effect for Polygenic Risk Score on the Rate of Subsequent Breast Cancer after Excluding Carriers of Predisposing Mutation

	Total survivorsa
	<45 years		≥45 years
Variable	RR (95% CI)	P	RR (95% CI)	P
PRS Quintile		0.011b		0.540b
1	Ref		Ref
2	0.4 (0.1 – 1.8)	0.22	1.3 (0.3 – 6.0)	0.69
3	1.3 (0.4 – 4.4)	0.71	3.5 (0.9 – 14.4)	0.08
4	1.7 (0.6 – 4.9)	0.29	2.5 (0.4 – 14.6)	0.30
5	3.2 (1.2 – 8.3)	0.02	0.7 (0.1 – 7.3)	0.79

^aModel did not converge for either chest RT or non chest-RT survivors.

^bP value for trend for PRS